Design, Develop and Evaluate a Sustainable Pharmaceutical Packaging Using Biodegradable Polymers

Abstract

As a sustainable substitute for traditional petrochemical-based plastics, this study explores the creation and improvement of biodegradable PLA–PHB (polylactic acid–polyhydroxybutyrate) blends for pharmaceutical packaging applications. Solvent casting was used to create a variety of formulations (F1–F7) with varying compositional ratios, and their mechanical, thermal, barrier, biological, and environmental performance were assessed. According to the study, PLA-rich blends had minimal migration characteristics, excellent tensile strength, and thermal stability, which made them appropriate for rigid packaging with a long shelf life. PHB-rich blends, on the other hand, showed improved biodegradability, encouraging eco-friendly disposal. The addition of amber-modified formulations enhanced their antibacterial and UV protection qualities, making them perfect for medicinal goods that are sensitive to light. Extensive evaluation tests, such as DSC, TGA, antibacterial activity, and stability investigations, verified that optimized blends like F2, F4, and F6 satisfy crucial pharmaceutical standards of durability, safety, and sterility. Overall, the study shows that PLA–PHB blends are promising, environmentally friendly materials that can take the place of traditional polymers in pharmaceutical packaging while maintaining performance effectiveness and regulatory compliance.