Phytochemical Screening and Antifungal Evaluation of Calotropis gigantea Leaf Extracts It in Topical Cream Formulation

Abstract

The study focuses on the development and evaluation of a herbal antifungal cream using Calotropis gigantea leaf extract. The plant contains bioactive compounds such as flavonoids, tannins, and glycosides, which contribute to antimicrobial, anti-inflammatory, and wound-healing properties. The formulation also includes supportive herbal ingredients like aloe vera, neem, and turmeric to enhance effectiveness. The cream was prepared through systematic processes including extraction, formulation, and in-vitro testing against Candida albicans. The developed formulations showed acceptable physical characteristics, stability, skin safety, and no microbial contamination. Among the formulations, F3 exhibited the highest antifungal activity with a 16 mm zone of inhibition. The study concludes that the herbal cream is a safe, cost-effective, and promising alternative to conventional antifungal treatments with fewer side effects and good patient acceptability.